THE POTENTIAL OF COMBINED ETHANOL EXTRACTS OF SAGA AND SEMBUKAN LEAVES IN REDUCING CHOLESTEROL LEVELS IN HYPERCHOLESTEROLEMIC MICE

Ulfatul Fadila; Gaby Ayu Patricia; Khoirul Ngibad

doi:10.34035/jk.v17i1.1749

Authors

Ulfatul Fadila Medical Laboratory Technology Program, Faculty of Health Sciences, Universitas Maarif Hasyim Latif, Sidoarjo, Indonesia
Gaby Ayu Patricia Medical Laboratory Technology Program, Faculty of Health Sciences, Universitas Maarif Hasyim Latif, Sidoarjo, Indonesia
Khoirul Ngibad Medical Laboratory Technology Program, Faculty of Health Sciences, Universitas Maarif Hasyim Latif, Sidoarjo, Indonesia

DOI:

https://doi.org/10.34035/jk.v17i1.1749

Keywords:

ethanol extract combination, hypercholesterolemia, mice (Mus musculus), saga leaves, sembukan leaves

Abstract

Background: To date, no research has explored the synergistic potential between saga leaves (Adenanthera pavonina L.) and sembukan leaves (Paederia foetida L.) in increasing the effectiveness of lowering cholesterol levels. This study aims to evaluate the potential of the combination of saga leaf ethanol extract and sembukan leaf in lowering cholesterol levels in hypercholesterolemia mice.
Methods: The study used 36 mice divided into six treatment groups, including a negative control group, a positive control, a drug control, and a treatment group with different doses of a combination of ethanol extract of Saga leaves and Sembukan leaves. The spectrophotometer measured lipid levels on days 0, 21, and 24. Data analysis was done using the one-way ANOVA test to determine group differences.
Results: The analysis showed that the combination of ethanol extract of saga leaves and sembukan leaves significantly reduced the cholesterol levels of hypercholesterolemia mice (p=0.000). The best dose for cholesterol reduction is 56 mg/20 g body weight (BW) with a 66% reduction.
Conclusion: Combining ethanol extract of saga leaves and sembukan leaves at a dose of 56 mg/20 g body weight (BW) effectively reduced cholesterol levels in hypercholesterolemia mice. This research may contribute to developing alternative natural therapies to lower cholesterol levels and prevent cardiovascular disease.

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